10 Things You Need to Know About DNA & RNA Vaccines for Livestock
Source: Corey’s Digs
10 Things You Need to Know About DNA & RNA Vaccines for Livestock
June 7, 2023
By The Sharp Edge
1. What are the different terms used for DNA or RNA-based veterinary biologics?
Not all genetic technologies used in veterinary medicine fall under the categories of “mRNA vaccines” or “mRNA gene therapies.” There are other terms to look out for when it comes to genetic technologies for veterinary medicine. These terms also include:
“RNA Particle Technology”
“RNA Particle Platform”
“DNA Vaccine”
“DNA Immunostimulant”
“Prescription Platform Product”
2. How do DNA or RNA-based veterinary biologics work?
With SEQUIVITY’s RNA Particle Technology, a “gene of interest provides instructions” to the immune cells which “translate the sequence into proteins” that “act as antigens.” This triggers an immune response.
As for AgriLab’s ExactVac DNA technology, “the vaccine is produced by splicing a gene for a specific antigen” into “a bacterial plasmid” which “is then multiplied, purified and administered” for “delivery into target cells, where antigens produced by the plasmid elicit an immune response.”
Bayer’s Zelnate DNA immunostimulant is “made up of a special type of immunostimulatory DNA surrounded by a lipid carrier or liposome” which is then “engulfed by the animal’s immune cell” where the “liposome breaks down exposing the DNA” and the “pathogen-associated molecular pattern” of the DNA “attaches to the immune cell’s toll-like receptors triggering activation of the immune cell.”
3. Which agency approves veterinary biologics?
The USDA’s Animal and Plant Health Inspection Service (APHIS) and their Center for Veterinary Biologics is responsible for approving veterinary biological products including vaccines and DNA or RNA-based biologics. Here are the lists of the currently licensed veterinary biological products and biologics for aquatic animals.
4. Which DNA or RNA-based biologics have been approved for food animals?
There are several DNA and RNA-based genetic technologies that have received USDA approval or conditional approval for use on chickens, cows, fish, and pigs as outlined below.
Chickens
In September 2015, Harrisvaccines received a USDA conditional license for an RNA-based avian influenza vaccine. Harrisvaccines “employs their unique SirraVaxSM RNA Particle (RP) technology platform” which can be updated to match current and future avian flu strains. In October 2015, Harrisvaccines was awarded a USDA stockpile contract of 48 million doses of their “pioneering RNA particle vaccine.” In November 2015, Merck acquired Harrisvaccines.
In November 2017, AgriLabs received USDA conditional approval for “the first DNA vaccine ever licensed for chickens” for avian flu using “AgriLabs’ ExactVac DNA technology with ENABL adjuvant.” In January 2018, Huvepharma acquired AgriLabs. Huvepharma’s DNA-based avian influenza vaccine has a conditional license on APHIS’s most recent list of approved veterinary biological products.
Cows
Bayer’s Zelnate DNA Immunostimulant received USDA approval for use against bovine respiratory disease (BRD) in January 2014. Zelnate is the “first-of-its-kind” DNA immunostimulant that is a genetic technology rather than a vaccine or antibiotic. Bayer’s DNA immunostimulant is on APHIS’s most recent list of approved veterinary biological products.
Fish
Elanco’s Apex IHN DNA vaccine for salmonids against Infectious Hematopoietic Necrosis Virus (IHNV) has received USDA approval and is on APHIS’s most recent list of licensed biologics for aquatic animals. Elanco’s DNA technology uses “relevant genetic components of the virus” that are inserted into a plasmid and injected into the muscle, after which the plasmid “instructs cells to produce antigens, which initiate an immune response.”
Pigs
In June 2014, Harrisvaccines became the first in the nation to receive USDA conditional licensing for their RNA-based PEDv vaccine for pigs. In November 2015, Merck acquired Harrisvaccines. Merck’s “RNA particle platform” for Coronavirus and Porcine Epidemic Diarrhea Vaccine (PEDv) has conditional approval by the USDA and this product has conditional licensing on APHIS’s most recent list of veterinary biological products.
In December 2017, AgriLabs received USDA approval for a DNA-based swine flu vaccine. In January 2018, Huvepharma acquired AgriLabs. Huvepharma’s ExactVac DNA-based swine flu vaccine is on APHIS’s most recent list of approved veterinary biological products.
In 2020, Huvepharma’s DNA-based vaccine platform for pigs received USDA approval as a “prescription platform product” so that the “manufacturer may update the gene insert in this vaccine under expedited procedures to respond to emerging needs.” Huvepharma’s DNA-based swine vaccine platform has conditional licensing as a prescription product on APHIS’s most recent list of approved veterinary biological products.
In 2020 and 2021, Merck’s Sequivity RNA vaccines for strains of swine influenza, which use “RNA particle technology,” were approved by the USDA and are on APHIS’s most recent list of approved veterinary biological products.
Also in 2021, Merck’s RNA particle technology, for use as a “prescription platform product,” was conditionally approved by the USDA and has conditional licensing on APHIS’s most recent list of veterinary biological products.
5. Is there ongoing research into DNA or RNA-based veterinary biologics?
There are a number of ongoing studies on DNA and RNA-based genetic technologies for veterinary medicine, as outlined below.
Bayer Partners with BioNTech to Develop mRNA Vaccines, Drugs for Animal Health, May 2016
Development of a Self-amplifying mRNA Vaccine for African Swine Fever and Classical Swine Fever, Start Date: Jun 1, 2021, End Date: May 31, 2024
Development of mRNA-based Vaccines for Heterosubtypic Protection Against Infectious Bronchitis and Infectious Laryngotracheitis Viruses, Start Date: Oct 1, 2021, End Date: Sep 30, 2023
mRNA Vaccine Development for Emerging Animal and Zoonotic Diseases, February 2022
Novel mRNA Vaccine Technology for Prevention of Bovine Respiratory Syncytial Virus, Start Date Oct 1, 2021, End Date Sep 30, 2026
Novel Vaccine Technologies in Veterinary Medicine: A Herald to Human Medicine Vaccines, April 2021
Vaccines to Reduce Salmonella Infantis in Chickens, Start Date: Sep 1, 2022, End Date: Oct 1, 2024
6. Is it possible for mRNA vaccines in livestock to contaminate meat, dairy or egg products?
According to a recent Epoch Times report, a 2014 USDA presentation on Vaccination for Contagious Diseases states that food animals receiving vaccines are subject to “mandatory withdrawal periods prior to slaughter for human consumption. Animals may not be sent to market until the withdrawal time has elapsed. During the mandatory withdrawal time vaccinated animals or products from vaccinated animals may not enter the food chain. The withdrawal time is determined by the country in which the vaccine is licensed and stated in the product license.” As the Epoch Times report notes, the USDA recognizes that there must be a waiting time between vaccination and slaughter for human consumption due to risks of contaminating the food supply. The USDA presentation does not, however, acknowledge DNA or RNA-based biologics, but the same standard of waiting times likely applies, as evidenced by Merck’s RNA vaccine for pigs, which states “Do not vaccinate within 21 days before slaughter.” However, Dr. Peter McCullough notes that mRNA technology “is far more durable than we ever could’ve imagined. It lasts in the human body for months unchanged.” Therefore, even with standard wait times, Dr. McCullough believes it is conceivable that mRNA technology administered to food animals could contaminate the food supply.
With that said, the Epoch Times report found “zero peer-reviewed studies looking into the transmissibility of mRNA vaccines from livestock to humans via either milk or meat.” Dr. Peter McCullough has warned that developers of novel vaccine technologies for veterinary medicine are “blinded with infatuation for molecular biology and have lost sight of biological product safety in the food supply” adding that they have failed to acknowledge the “possibility of collateral impact to humans.” In addition, Dr. McCullough has raised concerns regarding transmissibility based on a recent study which loaded cow’s milk with mRNA, and by consuming the milk, mice were successfully administered a Covid vaccine. Dr. McCullough points out the “considerable ethical issues” this research presents, with a large segment of the public having “strong objections to mRNA in the food supply, particularly if it was done surreptitiously or with minimal labelling/warnings.”
7. Are there labeling requirements for meats, dairy or eggs that may have been contaminated by DNA or RNA-based veterinary biologics?
The required labeling for meat, dairy and egg products is not transparent about possible exposure to DNA or RNA-based veterinary biologics. The USDA does, however, require “Bioengineered” labeling for foods that “contain detectable genetic material that has been modified through certain lab techniques and cannot be created through conventional breeding or found in nature.” It is unclear whether the USDA’s testing process for “detectable genetic material” is capable of picking up traces of genetic material from biologics used in veterinary medicine.
Moreover, the USDA’s “Organic” labeling does appear to permit vaccines for livestock used for meat, dairy and eggs, though the requirements state that animals must not be given hormones or antibiotics. A 2013 Agricultural Marketing Service document states that “organic livestock must be: – Produced without genetic engineering.” However, the same document goes on to say that “Only a few drugs, such as vaccines, are allowed” for organically raised livestock.
Furthermore, in many cases, labeling is not clear about the country from which meats originate. Country of Origin Labeling (COOL) requirements were dropped for beef and pork in 2016. COOL requirements remain in place for lamb, goat, chicken, and fish. Additionally, USDA regulations on meat, poultry and eggs have enabled “Product of USA” labeling for animals born and raised in other countries and only processed in the U.S. However, in March 2023, the USDA proposed a new rule to restrict labeling for “Product of USA” or “Made in the USA” to be used on “meat, poultry and egg products only when they are derived from animals born, raised, slaughtered and processed in the United States.”
8. Which organizations are behind this agenda?
According to a Corey’s Digs report, Codex Alimentarius was established by the UN’s Food and Agriculture Organization (FAO) and the WHO, for “the sole purpose of setting the standards and guidelines for all food that is consumed by human beings.” The report states that Codex does not have the authority to make laws, “so the 189 country members, 20 of which are heads of the various committees, take these ‘standards’ and create regulations and laws in their respective country. The USDA, for example, is a driving force for not only adhering to the standards, but making certain other countries follow in lock step as well.” Codex Alimentarius plays “a key role” in the implementation of new technologies within food standards, including “genetic editing” and “nanotechnology applications in the food sector” as well as “alternative food proteins.”
9. What are lawmakers, producers and concerned citizens doing to protect against contamination of the food supply from mRNA vaccines?
Lawmakers have proposed legislation in Arizona, Idaho, Missouri, South Carolina, Tennessee, and Texas to prohibit mRNA in meats or to require disclosure in food labeling. While legislation in Missouri and Idaho failed, efforts to block mRNA vaccines in livestock remain ongoing in other states.
A trade group, known as The Beef Initiative, has pledged that their Beef Box producers will not “use any mRNA vaccines in their livestock.” Over 100 producers are partnered with The Beef Initiative and can be found here.
Attorney Tom Renz has spearheaded the movement by states for transparency and disclosure of mRNA gene therapies in the food supply. Renz helped to draft Missouri’s HB1169. Naomi Wolf of Daily Clout is also promoting the cause. Doctor Peter McCullough has raised awareness on the issue of genetic technologies used in veterinary medicine and the potential dangers to the food supply in recent interviews and on substack publications.
10. What can the public do about it?
Stay informed and inform others by sharing this information. Additional resources on this topic are listed below. Support lawmakers and advocacy groups pushing for transparency and blocking DNA or RNA-based biologics from entering the food supply. Know what’s in your food and who is producing it. Buy from producers that have pledged to never use DNA or RNA-based genetic technologies, such as The Beef Initiative. Corey’s Digs has also published an excellent resource for finding high-quality foods as well as an incredible source for US Prime and High Choice Beef.
Additional Resources:
Chinese Load Cow’s Milk with mRNA Exosomes – Successfully Immunize Mice – Dr. Peter McCullough
Covid Vaccines ‘Opened the Floodgates’ for New Wave of mRNA Vaccines for Livestock – The Defender
Data on miRNA Transfer from Food into Human Body are Inconclusive, New Concerns of Genetic Material in Food Supply Spur Review of Research on Transmission – Dr. Peter McCullough
Eat Your Vaccines!… I Mean Vegetables! – Tom Renz
Eat Your Vaccines: mRNA Gene Therapy is Coming to the Food Supply THIS MONTH – Daily Clout
Finding Sources of Fresh Food – Corey’s Digs
Funding the Control Grid Part 3: The Food Framework – Corey’s Digs
Inside Codex with Scott Tips: New Global Food Diet – Insects, Rats and Dogs – Corey’s Digs
“Pharma Food” with Elze van Hamelen – Corey’s Digs
Novel Vaccine Technologies in Veterinary Medicine: A Herald to Human Medicine Vaccines, Explosion of Genetic Vaccines in Animals Gets Human Attention – Dr. Peter McCullough
The Shocking Truth About Edible mRNA Vaccines in Our Food (Part 2) – Epoch Times
Dig It! #189: WHO Covid Passports, CBDCs, mRNA in Livestock & More
In this week's podcast we talk about the WHO & EU initiative on global digital health certificates, several pilot programs rolling out, how states are combatting financial tyranny, and concerns about mRNA in livestock & the food supply.
audio version:
Corey's Digs reports:
10 Things You Need to Know About DNA & RNA Vaccines for Livestock
https://www.coreysdigs.com/food-supply-chain/10-things-you-need-to-know-about-dna-rna-vaccines-for-livestock/
Is Your State Protecting Financial Freedom? Get The Full Breakdown Here
https://www.coreysdigs.com/solutions/is-your-state-protecting-financial-freedom-get-the-full-breakdown-here/
A Look at 10 Red States Leading the Charge Against Financial Tyranny
https://www.coreysdigs.com/solutions/a-look-at-10-red-states-leading-the-charge-against-financial-tyranny/
Source: Children’s Health Defense
COVID Vaccines ‘Opened the Floodgates’ for New Wave of mRNA Vaccines for Livestock
Several new government- and industry-funded studies are underway to develop mRNA vaccines for livestock, but “we need to be sure that no abnormal cellular or molecular changes to the animal could be induced by this type of vaccine,” one scientist told The Defender.
Several new government- and industry-funded studies are underway to develop mRNA vaccines for livestock, part of the massive expansion of the animal vaccine industry projected to be worth $26.12 billion by 2030.
Researchers at Iowa State University are undertaking a project funded by the U.S. Department of Agriculture to develop mRNA vaccine technology to prevent bovine respiratory syncytial virus (RSV).
Pharmaceutical company Zoetis developed an mRNA COVID-19 vaccine for animals that was administered to animals at zoos throughout the country.
And researchers in the U.S. Fish and Wildlife Service experimented with vaccinating captive-bred black-footed ferrets against COVID-19. They also experimented with social distancing and quarantine of ferrets.
“Third generation vaccines,” including DNA, RNA and recombinant viral vector vaccines, are not only administered to livestock — but they also are being developed for companion animals and wild animals.
A peer-reviewed study in the journal Viruses last year reported, “The successful application of mRNA vaccines against COVID-19 has further validated the platform and opened the floodgates to mRNA vaccine’s potential in infectious disease prevention, especially in the veterinary field.”
Citing the need for biosecurity, in September 2022, the New South Wales (NSW) government fast-tracked the world’s first mRNA vaccines for foot-and-mouth disease and lumpy-skin disease, in a five-year multimillion dollar deal with U.S. biotech company Tiba Biotech.
Announcing the deal, Deputy Premier and Minister for Regional NSW Paul Toole said:
“I have now written to vaccine manufacturers to take up my challenge to develop both vaccines ready for use and manufacture in NSW by August 1 next year.
“COVID-19 demonstrated to us that all possible avenues in developing vaccines must be explored and we will leave no stone unturned.”
Dugald Saunders, NSW minister for agriculture, emphasized how important it was to “protect [NSW’s] livestock sector” and said the agreement with Tiba Biotech to create mRNA vaccines, “would be a game-changer for the industry.”
But experts have raised concerns. Holistic veterinarian Dr. W. Jean Dodds, told The Defender in an email:
“Not enough is known at this time if mRNA vaccines can generate any long-term effects on reproduction or lifespan of domestic farm stock.
“As livestock become part of the human and animal food chain, we need to be sure that no abnormal cellular or molecular changes to the animal could be induced by this type of vaccine.”
‘Good health starts with biosecurity’
According to a report published last year by Grand View Research, the market for animal vaccines is expected to grow at a 9.3% compounded annual growth rate, because “the growing incidence of food-borne zoonotic diseases and increasing animal husbandry are boosting the demand for vaccines.”
The paper pointed to the potential of the mRNA platform to treat diseases like African swine fever, porcine reproductive and respiratory syndrome virus, porcine epidemic diarrhea virus, foot-and-mouth disease virus, bovine viral diarrhea virus, lumpy skin disease virus, bovine leukemia virus and peste des petits ruminants virus, among others.
A recent white paper, “The Future of Livestock Vaccines,” by researchers at the Livestock Research Innovation Corporation, Ontario, Canada, summed up the shift in thinking about animal vaccines:
“New technologies (e.g. mRNA, artificial intelligence) will have dramatic impact on the availability and effectiveness of vaccines available to producers. …
“The current COVID-19 pandemic has taught us many lessons, including the fact that the development, mass production and approval process of vaccines could be shortened from several years (or decades) to 8-9 months.”
“Good health starts with biosecurity,” the authors stated.
Iowa State teams up with Merck — with help from the U.S. government
Iowa State University and Merck last year announced a four-year strategic alliance to research “emerging technologies” in animal health.
Their joint research project to develop mRNA vaccine technology to prevent bovine RSV, as stated above, is funded in part by the U.S. government.
The study aims to develop a novel mRNA platform that is cost-efficient and thermostable in order to “open the door for vaccinating production animals with this technology.”
The project seeks to develop the platform for a bovine RSV vaccine “as a proof of principle for development of vaccines against this pathogen but also as a platform technology for other vaccines as well.”
In 2018, Merck Animal Health introduced Sequivity technology, “a revolutionary swine vaccine platform,” according to its website, to customize vaccines for various swine viruses using RNA particle technology.
The technology consists of creating electronic gene sequences for a given disease, synthesizing them into RNA, inserting them into the platform and injecting them into the animal. The RNA provides instructions to the immune cells to translate the sequence into proteins, which act as antigens.
Merck scientists developed the technology in partnership with Iowa State’s College of Veterinary Medicine.
Gates Foundation among funders of vaccines for livestock
For decades, concentrated animal feedlot operations, known as CAFOs, used antibiotics to help prevent bacterial infections from spreading through farm spaces densely packed with animals. The antibiotics also make animals grow faster.
After years of growing public concern about the use of antibiotics in meat production — particularly for the antibiotic residues they leave and their role in the development of drug-resistant “superbugs” — the World Health Organization in 2017 developed a set of guidelines and best practices on the use of medically important antimicrobials in animals raised for food.
That same year, the U.S. Food and Drug Administration (FDA) began regulatory measures to prevent the use of livestock antibiotics for growth purposes and required farmers who wanted to use antibiotics to get them from veterinarians.
The FDA finalized that guidance in 2021.
In an effort to reduce the use of publicly spurned antibiotics and to deal with the problem of viral infections common in industrial livestock production, meat producers turned to vaccines.
“Vaccines and other alternative products can help minimize the need for antibiotics by preventing and controlling infectious diseases in animal populations, and are central to the future success of animal agriculture,” according to a 2018 article in Veterinary Research.
Animal vaccines commonly require a lower level of scrutiny than vaccines for humans.
According to a 2016 Bloomberg report, industry leaders like Elanco, Eli Lilly, Merck Animal Health and Zoetis began shifting billions of dollars of research investments from antibiotics to vaccines in advance of the 2017 FDA regulatory measures.
Experts predicted the new regulations would cause the market for vaccines to explode.
A 2022 report by Acumen showed that other major pharmaceutical companies, including Ceva, Boehringer Ingelheim International GmbH, Neogen Corporation, Intas Pharmaceuticals, Zoetis, Biogénesis Bagó and Pfizer are heavily investing in the animal vaccine industry.
“The future of our company is heavily grounded in vaccine development,” Dr. Rick Sibbel, a veterinarian who ran Merck’s technical services for cattle, poultry and swine, told Bloomberg.
The U.K.’s Department for International Development partnered with the Bill & Melinda Gates Foundation to fund livestock vaccines around the world, the department tweeted in 2018:
Bill Gates explains why #UKaid is partnering with @GatesFoundation to fund groundbreaking research to protect agriculture and farmers from around the world against devastating diseases #AidWorks pic.twitter.com/NIuI75cnkE
— DFID (@DFID_UK) January 26, 2018
That partnership included a $40 million grant in 2017 to develop new livestock vaccines. Gates Foundation funding to CGIAR, “global research partnership for a food-secure future dedicated to transforming food, land, and water systems in a climate crisis,” continues to focus on shifting livestock producers from using antibiotics to vaccines.
Source: Modern Farmer
FDA Approves First CRISPR Cows For Beef
The genome-edited cattle were bred to endure climate change, and their offspring will be used in meat production.
Mar 23, 2022
By Shea Swenson
Earlier this month, the FDA approved genome-edited cattle for use in meat production. They were bred with climate change in mind, and they have extremely slick, short hair, which is said to help the animals cope with hot weather more effectively.
The cattle breed, known as PRLR-SLICK, was developed using a genome-editing technique called CRISPR, which is used to breed animals with specific traits. Unlike genetically modified organisms (GMO), which typically involve adding genetic material from other organisms and result in a plant or animal that would not exist in nature, gene-editing utilizes genes already native in a species, resulting in an organism that could, theoretically, occur through a natural breeding process.
The federal agency called the decision to introduce the beef cattle to be raised for meat “low risk” after determining that the intentional genomic alteration (IGA) of the cattle does not cause any safety concerns. Pending a forthcoming safety review, the meat could land on shelves in as little as two years.
In a press release, the FDA explained that IGAs are “alterations made using molecular technologies that introduce changes to the genome of an animal.” According to Successful Farming, a “precision breeding” company called Acceligen in Minnesota is responsible for utilizing the CRISPR technique to produce the slick-coat cattle. It’s not the first to use the technology on cows, however. In 2020, researchers at UC Davis used CRISPR technology to breed a cow, named Cosmo, designed to produce 75-percent male offspring.
In the past, the FDA has approved similar genetic modifications in salmon, goat, chicken, rabbit and, most recently, pigs. However, the PRLR-SLICK cattle are the first to receive an official “low-risk determination for enforcement discretion,” meaning the administration deemed there are no practical differences in the final product (meat) made by the gene-edited cattle and conventionally bred cattle.
With the slick-coat trait occurring naturally in some cattle, the gene-edited cattle are the same—as far as a consumer is concerned—as other cattle with the same traits. “Further, the food from the cattle is the same as food from conventionally bred cattle that have the same slick-hair trait,” said the FDA.
The FDA reviewed genomic data and other information provided by the developer to reach its safety determination.
Steven Solomon, director of the FDA’s Center for Veterinary Medicine, said in the press release that the decision will likely pave the way for future gene editing. “We expect that our decision will encourage other developers to bring animal biotechnology products forward for the FDA’s risk determination in this rapidly developing field, paving the way for animals containing low-risk IGAs to more efficiently reach the marketplace.”
Farmers that plan to use the PRLR-SLICK cattle will not have to register with the administration.
Confused About MRNA Vaccines in Meat? That’s Exactly How They Want It.
This is yet another reason why you need to secure your food supply now.
We talk a lot about the importance of securing food supplies on this site, both to avoid novelty products like insects, and also for peace of mind. This most recent revelation about pork products already being treated with mRNA and refusal by industry representatives to address anything other than how HB 1169 will affect the business community should serve as yet another wake up call. We cannot assume anything we buy at the store has not been treated with novel pharmaceutical products.
I know some people will disagree about calling mRNA vaccines “novel products.”
“We’ve been researching mRNA for decades!” I’ll hear. We have not been ingesting these products for decades; we’ve been ingesting them for about five years, without our knowledge, and no one has been monitoring results. This is not enough for me to be confident in their safety, and I don’t think it should be enough for anyone else, either.
I haven’t bought meat from the grocery store in a long time, mostly because I produce a lot myself. Of course, meat production is not practical for everyone, but if it is an option for you, you need to think about it.
And if not, ask yourself, are there farms in your area committed to raising clean meat? There might be. These types of places often have some kind of subscription service and are worth checking out. Even if there is nothing very close, there are some places that ship. Or it might be worth a road trip to get a year’s worth of meat. If you don’t already have good meat sources, now is the best time to start looking for them.
If you live in Missouri, I hope you can raise public awareness about this bill. For those of us that do not, we need to take responsibility for our food choices and start looking for meat sources outside the normal system.
TFTC #413: Resisting mRNA Food with Charles Mayfield
Marty sits down with Charles Mayfield to talk about Keto Con, the wonders of pig biology, and the destruction of food and agriculture wrought by corporations and legislation.
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